反应详情

温度

5 °C

A solution of 46.0 g of ethyl cyano-[4-(1E-pentenyl)cyclohexylidene]acetate in 120 ml of ethanol is added dropwise at 5°-10° C. within 40 minutes to a mixture of 6.7 g of sodium borohydride and 120 ml of ethanol. The reaction mixture is stirred at 5° C. for 45 minutes, then diluted with 750 ml of water and extracted with three 250 ml portions of diethyl ether. The extract is washed neutral with water, dried over sodium sulphate and concentrated. There is obtained crude ethyl cyano-[trans-4-(1E-pentenyl)cyclohexyl]acetate (cis content <20%).

1. extractionextracted with three 250 ml portions of diethyl ether
2. washThe extract is washed neutral with water
3. dry with materialdried over sodium sulphate
4. concentrationconcentrated