Water → HCID 14998348, compound

Participants

Reaction Conditions

Reaction Steps

3-[7-fluoro-4-propargyl-2H-1,4-bezoxazin-3(4H)-on-6-yl]-5-isopropylidenehydantoin (1.2 g), potassium carbonate (3.0 g) and iodomethane (3.0 g) were dissolved in N,N-dimethylformamide (30 ml), followed by heating at 70° C. for 6 hours. The reaction mixture was allowed to cool, combined with water and extracted with ethyl acetate. The organic layer was purified by silica gel column chromatography using a mixture of toluene and ethyl acetate as the eluent to give Compound No. 32 (1.1 g).

Provenance & Evidence