HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Toluenesulfonyl chloride → 1-Benzylpyrrolidin-3-yl 4-methylbenzenesulfonate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Toluenesulfonyl chloride | HCID 7397 | — |
| Reactant | N-benzyl-3-pyrrolidinol | HCID 69889 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 1-Benzylpyrrolidin-3-yl 4-methylbenzenesulfonate | HCID 15623668 | — |
Reaction Steps
2.39 g (12.4 mmoles) of toluene-4-sulfonyl chloride, dissolved in 10 ml of pyridine, were added dropwise, under nitrogen atmosphere, to a stirred solution of 2.0 g (11.3 mmoles) of N- benzyl-3-hydroxypyrrolidine [J. Med. Pharm. Chem. 1, (1959) 73,76,77]in 15 ml of pyridine, cooled below -10° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05322848 |
| Source dataset | uspto-grants-1994_06 |
| ORD ID | ord-036785c6cb2542d2a34d1350e3fcc745 |
| Source note | uspto-grants-1994_06 |