Acetic Acid → HCID 67692089, compound

HRID 1109727Notes

Reaction equation

HRID 1109727 reaction equation
C([N:8]1[CH2:12][CH2:11][CH:10]([F:13])[CH2:9]1)C1C=CC=CC=1.[C:14]([OH:17])(=[O:16])[CH3:15]>CO.[Pd]>[C:14]([OH:17])(=[O:16])[CH3:15].[F:13][CH:10]1[CH2:11][CH2:12][NH:8][CH2:9]1

Participants

5

Reactant 2

HCID 176Acetic AcidHCID 10375011HCID 10375011, compound

Product 1

HCID 67692089HCID 67692089, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

0.3 g (1.67 mmoles) of N-benzyl-3-fluoropyrrolidine, dissolved in 20 ml of methanol containing 2.1 ml of acetic acid, were hydrogenated at room temperature in a Parr apparatus at 50 psi in the presence of a catalytic amount of 10% Pd on charcoal, until the theoretical amount of H2 was consumed.

Workup

  1. customwas consumed

Sources & evidence

ORD record
ord-143a85d6d2c04f238a519fad22b66c93
Source dataset
uspto-grants-1994_06
Patent number
US05322848

Reaction notes

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