HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1109728Generated: October 26, 2026
Methyl iodide → N-benzyl-3-methoxypyrrolidine
https://huagongshe.com/reaction/1109728
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | N-benzyl-3-pyrrolidinol | HCID 69889 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | N-benzyl-3-methoxypyrrolidine | HCID 19019527 | — |
Reaction Steps
A solution of 2.0 g (11 3 mmoles) of N-benzyl-3-hydroxypyrrolidine in 10 ml of dry THF was added dropwise at room temperature to a stirred slurry of 0.53 g (12.4 mmoles) of 56% NaH in 10 ml of dry THF, under nitrogen atmosphere. After 2 h the solution was cooled to 0° C. and 1.8 g (12.4 mmoles) of methyl iodide were added.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05322848 |
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| Source dataset | uspto-grants-1994_06 |
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| ORD ID | ord-836d2f4307b84e34875640e5f705b258 |
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| Source note | uspto-grants-1994_06 |
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