HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Fluoride → Phenylmethyl (3S)-3-fluoro-1-pyrrolidinecarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Fluoride | HCID 522689 | — |
| Reactant | (R)-(-)-1-CBZ-3-pyrrolidinol | HCID 11183628 | — |
| Solvent | Ethylene Glycol | HCID 174 | — |
| Product | Phenylmethyl (3S)-3-fluoro-1-pyrrolidinecarboxylate | HCID 15197579 | — |
Reaction Steps
A stirred mixture of 20.85 g (0.360 moles) of potassium fluoride spray-dried and 18.0 g (0.048 moles) of (3R)-N- benzyloxycarbonyl-3-hydroxypyrrolidine in 160 ml of freshly distilled ethylene glycol was kept at 85° C. for 15 h under nitrogen atmosphere.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05322848 |
| Source dataset | uspto-grants-1994_06 |
| ORD ID | ord-b6e13fdfdacb4d11a3f0b479fc059b0f |
| Source note | uspto-grants-1994_06 |