HRID1109765

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID102

3-Hydroxybenzyl alcohol

C7H8O2

HCID14204205

未命名化合物

结构：OCc1cccc(OCc2nc3cc(C(F)(F)F)ccc3s2)c1

HCID53867966

未命名化合物

PRODUCTS

生成物

HCID11397

2,7-Naphthalenediol

C10H8O2

HCID11241007

2-(chloromethyl)-6-fluoro-quinoline

C10H7ClFN

HCID14204210

未命名化合物

HCID19019454

未命名化合物

PROCEDURE

实验过程

In a similar manner, starting with 2-chloromethyl-5-trifluoromethylbenzothiazole and 3-hydroxy benzyl alcohol and following this procedure, 3-(5-trifluoromethylbenzothiazol-2-ylmethoxy)benzyl alcohol was prepared, m.p. 117°-119° C., 2-chloromethyl-5-fluorobenzothiazole and 2,7-dihydroxynaphthalene gave 2-(5-fluorobenzothiazol-2-ylmethoxy)-7-hydroxynaphthalene, m.p. 218°-220° C., 2-chloromethyl-6-fluoroquinoline and m-resorcinol gave 3-(6-fluorocruinol-2-ylmethoxy)phenol, m.p. 146°-148° C. and 2-chloromethyl-5-fluorobenzothiazol and methyl 3-hydroxymandelate gave methyl 3-(5-fluorobenzothiazol-2-ylmethoxy)mandelate, m.p. 99°-101° C.

WORKUP

后处理

customwas prepared

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-6b4668dbade64491afd029d8e78a6fd4
来源数据集: uspto-grants-1994_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05322847
来源说明: uspto-grants-1994_06

反应 SMILES

[Cl:1][CH2:2][C:3]1[S:4][C:5]2[CH:11]=[CH:10][C:9](C(F)(F)[F:13])=[CH:8][C:6]=2[N:7]=1.[OH:16][C:17]1[CH:18]=[C:19]([CH:22]=[CH:23][CH:24]=1)[CH2:20]O.[F:25]C(F)(F)[C:27]1[CH:28]=[CH:29][C:30]2[S:34][C:33]([CH2:35][O:36][C:37]3[CH:38]=[C:39]([CH:42]=[CH:43][CH:44]=3)[CH2:40]O)=[N:32][C:31]=2[CH:45]=1>>[Cl:1][CH2:2][C:3]1[S:4][C:5]2[CH:11]=[CH:10][C:9]([F:25])=[CH:8][C:6]=2[N:7]=1.[OH:16][C:17]1[CH:24]=[CH:23][C:22]2[C:19](=[CH:20][C:37]([OH:36])=[CH:44][CH:43]=2)[CH:18]=1.[F:13][C:27]1[CH:28]=[CH:29][C:30]2[S:34][C:33]([CH2:35][O:36][C:37]3[CH:44]=[CH:43][C:42]4[C:39](=[CH:40][C:17]([OH:16])=[CH:24][CH:23]=4)[CH:38]=3)=[N:32][C:31]=2[CH:45]=1.[Cl:1][CH2:2][C:3]1[CH:24]=[CH:23][C:5]2[C:6](=[CH:8][CH:9]=[C:10]([F:25])[CH:11]=2)[N:7]=1