HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl Alcohol → 3-(5-Fluorobenzothiazol-2-yl-trans-ethenyl)benzyl alcohol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl Alcohol | HCID 244 | — |
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | Isophthalaldehyde | HCID 34777 | — |
| Reactant | 5-Fluoro-2-methylbenzothiazole | HCID 597437 | — |
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | 3-(5-Fluorobenzothiazol-2-yl-trans-ethenyl)benzaldehyde | HCID 86747932 | — |
| Catalyst | Zincchloride | HCID 3007855 | — |
| Solvent | O-Xylene | HCID 7237 | — |
| Product | 3-(5-Fluorobenzothiazol-2-yl-trans-ethenyl)benzyl alcohol | HCID 67828433 | — |
Reaction Steps
An alternate procedure for preparing this benzyl alcohol comprises condensing isophthalaldehyde with 2-methyl-5-fluorobenzothiazole in the presence of acetic anhydride and zinc chloride in hot xylene followed by the reduction of the 3-(5-fluorobenzothiazol-2-yl-trans-ethenyl)benzaldehyde product with sodium borohydride to provide the appropriate benzyl alcohol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05322847 |
| Source dataset | uspto-grants-1994_06 |
| ORD ID | ord-bebd70f669a54af8be82f17d90119462 |
| Source note | uspto-grants-1994_06 |