2-Chloroethanol → 1-chloro-3-(2-chloroethoxy)propan-2-ol

A mixture consisting of 100 g 2-chloroethanol (12.4 mol), 573 g epichlorohydrin (6.2 mol) and 20 g of an acidic ion exchange resin was refluxed for 24 hours. The mixture was then filtered to remove the ion exchange resin and the excess alcohol and unreacted epichlorohydrin were removed by distillation. The residue was distilled under vacuum and the product 1-chloro-3-(2-chloroethoxy)-2-propanol (804 g, 75% yield) distilled between 89° and 91° C. at 0.05 mm Hg.

1. temperaturewas refluxed for 24 hours
2. filtrationThe mixture was then filtered
3. customto remove the ion exchange resin
4. customthe excess alcohol and unreacted epichlorohydrin were removed by distillation
5. distillationThe residue was distilled under vacuum

ORD record

ord-8da5f0a9e5954dadbb6af0185e50c69c

Source dataset

uspto-grants-1994_06

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05322903