Hydrogen Sulfide → HCID 88428340, compound

Participants

Reaction Steps

The crude material of (2S,3S)-dimethyl-3-ethylaspartate hydrobromide (27.2 g) of Example 6 was suspended in water (200.0 mL) and filtered. The filter cake was washed with water (300.0 mL) 2nd the combined aqueous solution were diluted with methanol (500.0 mL). To this solution was added copper(II) carbonate copper(II) hydroxide (76.4 g, 345.5 mmol) and the resulting green suspension was mechanically stirred in a Morton flask (2.0 L) for 119 h. The suspension was saturated with hydrogen sulfide for 1 h, then the resulting black suspension was filtered through celite. The filter cake was washed with an aqueous solution of methanol (70%, 1800.0 mL). The combined filtrate and washings were concentrated in vacuo to give the amino acid salt (19.6 g) which was used for further reaction without purification.

Provenance & Evidence