反应详情

Sodium hydroxide (40% aqueous solution, 12.9 g, 0.129 mol) was added over 20 minutes to a stirred mixture of diethyl maleate (17.3 g, 0.1 mol) and hydroxylamine sulfate (25% aqueous, 39.0 g, 0.059 mol) during which the reaction temperature rose from 28° C. to 53° C. The reaction mixture was stirred for 30 minutes under nitrogen. The mixture was transferred to separating funnel, methylene chloride was added (50 ml), the organic layer was collected dried using anhydrous magnesium sulfate, and concentrated to give diethyl N-hydroxyaspartate (18.5 g, 0.99 mol, 90% yield).

1. customrose from 28° C. to 53° C
2. customto separating funnel
3. additionmethylene chloride was added (50 ml)
4. customthe organic layer was collected
5. customdried
6. concentrationconcentrated