化工社化工社 化学情報印刷レポート · 研究参考用
N-(Benzyloxy)-N-(4-cyanobutyl)-5-chloropentanamide → 14-Bromo-6-(benzyloxy)-7-oxo-6-azatetradecanenitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N-(Benzyloxy)-N-(4-cyanobutyl)-5-chloropentanamide | HCID 10087530 | — |
| 反応物 | 8-bromooctanoyl Chloride | HCID 11402228 | — |
| 反応物 | O-Benzyl-N-(4-cyanobutyl)hydroxylamine | HCID 14078488 | — |
| 反応物 | Ethyl acetate hexane | HCID 21226206 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 溶媒 | Sodium Hydroxide | HCID 14798 | — |
| 生成物 | 14-Bromo-6-(benzyloxy)-7-oxo-6-azatetradecanenitrile | HCID 9978855 | — |
反応手順
Compound 2 (n=4) (3.2 g, 15.7 mmol) was treated with 8-bromooctanoyl chloride (4.55 g, 18.8 mmol) in CH2Cl2 and 1N NaOH following the procedure used for (3). Silica gel column chromatography with 2:1 hexane/EtOAc afforded 3.8 g (59%) of [I] as an oil: NMR δ 1.17-2.00 (m, 14 H), 2.23-2.50 (m, 4 H), 3.37 (t, 2 H, J=6), 3.63 (t, 2 H, J=6), 4.77 (s, 2 H), 7.33 (s, 5 H). Anal. (C20H29BrN2O2) C, H, N.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05322961 |
| 出典データセット | uspto-grants-1994_06 |
| ORD ID | ord-469186e1e8df4a709aa89694ce671548 |
| 出典メモ | uspto-grants-1994_06 |