反应详情

Jones reagent (a 2.6M solution in sulfuric acid; 0.13 ml, 0.36 mmol) was added dropwise to a solution of 4-(5-hydroxy-3-hexadecynyl)-2-triethylsilylfuran (136.4 mg, 0.33 mmol) in acetone (5 ml) at 0 degrees. After 20 minutes, the excess Jones reagent was destroyed with ethanol (ca 1 ml) and the mixture was diluted with water. The organic phase was is separated, dried (magnesium sulfate) and evaporated down to give an oil, which was purified by preparative silica plates to give the titled ketone.

1. customthe excess Jones reagent was destroyed with ethanol (ca 1 ml)
2. additionthe mixture was diluted with water
3. customThe organic phase was is separated
4. dry with materialdried (magnesium sulfate)
5. customevaporated down
6. customto give an oil, which
7. customwas purified by preparative silica plates