Dicyclohexylcarbodiimide → HCID 178455787, compound

HRID 1109960Notes

Reaction equation

HRID 1109960 reaction equation
C1(N=C=NC2CCCCC2)CCCCC1.[F:16][C:17]([F:27])([F:26])[O:18][C:19]1[CH:24]=[CH:23][C:22]([OH:25])=[CH:21][CH:20]=1.CN(C1C=CC=CN=1)C.[CH2:37]([C@H:39]1[CH2:44][CH2:43][C@H:42]([C:45](O)=[O:46])[CH2:41][CH2:40]1)[CH3:38]>C1(C)C=CC=CC=1>[CH2:37]([C@H:39]1[CH2:44][CH2:43][C@H:42]([C:45]([O:25][C:22]2[CH:21]=[CH:20][C:19]([O:18][C:17]([F:26])([F:27])[F:16])=[CH:24][CH:23]=2)=[O:46])[CH2:41][CH2:40]1)[CH3:38]

Participants

6

Reactant 4

HCID 10868DicyclohexylcarbodiimideHCID 218852-DimethylaminopyridineHCID 70015p-(Trifluoromethoxy)phenolHCID 178455790HCID 178455790, compound

Product 1

HCID 178455787HCID 178455787, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent2×

Procedure

First, 4.6 g of dicyclohexylcarbodiimide in 80 ml of toluene are added to a mixture of 4 g of 4-trifluoromethoxyphenol and 20 ml of toluene, 0.2 g of dimethylaminopyridine is then added, the mixture is stirred at room temperature for I hour, and 3.8 g of trans-4-ethylcyclohexanecarboxylic acid are then added. After work-up and purification by chromatography and/or crystallization, 4-(trifluoromethoxy)phenyl trans-4-ethylcyclohexanecarboxylate is obtained.

Workup

  1. additionis then added
  2. additionare then added
  3. customAfter work-up and purification
  4. customby chromatography and/or crystallization

Sources & evidence

ORD record
ord-c48b02bc8c6d4b4a955494d01ea4e2b5
Source dataset
uspto-grants-1994_06
Patent number
US05324449

Reaction notes

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