Ammonia → HCID 178449849, compound

HRID 1109970Notes

Reaction equation

HRID 1109970 reaction equation
[NH2:1][CH:2]([C:6]([OH:8])=[O:7])[CH2:3][CH2:4][CH3:5].[PH2:9](=[O:11])[OH:10].[NH3:12]>CO>[NH2:1][CH:2]([C:6]([OH:8])=[O:7])[CH2:3][CH2:4][CH3:5].[NH4+:12].[PH2:9](=[O:10])[O-:11]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 178449848HCID 178449848, compound

Product 1

HCID 178449849HCID 178449849, compoundYield 97.5%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
65 °C

Procedure

181 g (1 mole) of (3-amino-3-carboxy-propyl)-methane-phosphinic acid are reacted at room temperature with 17 g (1.0 mole) of ammonia (previously dissolved at 0° C. in methanol). The mixture warms up spontaneously to 35° C. and is then refluxed at 65° C. for 30 minutes, cooled, filtered and the crystals are dried to give 193 g of (3-amino-3-carboxy-propyl)-methane-phosphinic acid ammonium salt, which is non-hygroscopic, readily soluble in water, melting at 207°-209° C., containing 90% of (3-amino-3-carboxy-propyl)-methane-phosphinic acid. Yield: 97.5%

Workup

  1. customwarms up spontaneously to 35° C.
  2. temperaturecooled
  3. filtrationfiltered
  4. customthe crystals are dried

Sources & evidence

ORD record
ord-1ef1201e55c4432e82138a4809e392a7
Source dataset
uspto-grants-1994_06
Patent number
US05324708

Reaction notes

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