Water → 6-Chloro-2-methylpyrimidine-4-carboxylic acid

HRID 1109980Notes

Reaction equation

HRID 1109980 reaction equation
[Cl:1][C:2]1[N:7]=[C:6]([CH3:8])[N:5]=[C:4]([C:9](Cl)=[O:10])[CH:3]=1.[OH2:12]>>[Cl:1][C:2]1[N:7]=[C:6]([CH3:8])[N:5]=[C:4]([C:9]([OH:10])=[O:12])[CH:3]=1

Participants

3

Reactant 2

HCID 962WaterHCID 190184816-Chloro-2-methylpyrimidine-4-carbonyl chloride

Product 1

HCID 190184786-Chloro-2-methylpyrimidine-4-carboxylic acid

Procedure

16 g of 6-chloro-2-methylpyrimidine-4-carbonyl chloride are added dropwise at 10°-15° C. to 150 ml of water. The mixture is then stirred for 1/2 h, the solid is filtered off with suction, and the filter residue is then washed well with water and dried in vacuo at 50° C. 11.5 g of 6-chloro-2-methylpyrimidine-4-carboxylic acid of melting point 132° C. (dec.) are obtained in this way.

Workup

  1. filtrationthe solid is filtered off with suction
  2. washthe filter residue is then washed well with water
  3. customdried in vacuo at 50° C

Sources & evidence

ORD record
ord-e33a187cf06841dbb0d56cca5ad4a0c3
Source dataset
uspto-grants-1994_06
Patent number
US05324710

Reaction notes

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