Sodium hydride → HCID 19018480, compound

Participants

Reaction Steps

0.44 g of sodium hydride suspension (60% strength in mineral oil) is added to a stirred solution of 2.4 g of 2-trifluoromethylbenzylsulfonamide in 40 ml of dimethoxyethane and stirring is continued until the evolution of hydrogen is complete. A solution of 2-chloro-6-methylpyrimidine-4-carbonyl chloride (from 2.1 g of carboxylic acid, 20 ml of dioxane, [lacuna] drops of dimethylformamide and 2.1 g of thionyl chloride) in 20 ml of dimethoxyethane is rapidly added dropwise to this. The mixture is then stirred at room temperature for 3 h and worked up as described in Example 13. 1.4 g of 2-trifluoromethyl-N-[(2-chloro-6-methylpyrimidin-4-yl)carbonyl]benzylsulfonamide of melting point 198°-199° C. are obtained in this way.

Provenance & Evidence