Water → HCID 19018639, compound

Participants

Reaction Conditions

Reaction Steps

Under a nitrogen atmosphere, 0.25 g of sodium hydride was added to 50 ml of dry dimethylformamide, and the solution was heated to a temperature of 80° C. A solution of 4 g of 2-(4-hydroxyphenyl)-1-{2-[4-(4-methylpyridin-2-yl)piperazin-1-yl]ethyl}-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinoline (preparation see Example 8) in 75 ml of dimethylformamide was then added. The reaction mixture was stirred for 10 minutes, whereupon it assumed a greenish coloration. A solution of 1.6 g of ethyl 4-bromobutyrate in 40 ml of dimethylformamide was then added, and the reaction mixture was heated at 80° C. for 30 minutes. The reaction mixture was worked up by adding water and then extracting with dichloromethane. The organic phase was separated, washed, dried and concentrated. The residue which remained was purified by chromatography on a silica gel column, toluene to which amounts of ethanol increasing to 2% had been added being used as the eluent. 1 g of oily ethyl 4-[4-[1-{2-[4-(4-methylpyridin-2-yl)piperazin-1-yl]ethyl}-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinoline-2-yl]-phenoxy]-butyrate was obtained.

Provenance & Evidence