Toluene → HCID 19018642, compound

Participants

Reaction Steps

A solution of 2.96 g of sodium cyanide in 60 ml of water was added to a solution of 14 g of 1-(2-bromoethyl)-5,6-dihydro-2-methyl-4H-pyrrolo[3,2,1-ij]quinoline in 100 ml of toluene, and the reaction mixture was heated under reflux for 4 hours. To work up the reaction mixture it was concentrated to dryness, and the residue was washed with water and extracted with dichloromethane. The dichloromethane phase was separated, dried and evaporated. 10.5 g of crude 1-(3-cyanopropyl)-5,6-dihydro-2-methyl-4H-pyrrolo[3,2,1-ij]-quinoline were obtained as a brownish oil.

Provenance & Evidence