Salicylic Acid → HCID 178448524, compound

Participants

Reaction Steps

10.7 g (=0.037 mole) of bertosamil were dissolved in 40 ml of diethyl ether. A solution of 5.12 g (=0.037 mole) of salicylic acid in 30 ml of diethyl ether was added to the solution, and the reaction mixture was stirred for 30 minutes. The resulting precipitate was filtered out of the mother liquor using a suction filter, and dried at 60° C. in a vacuum drying oven. 14.5 g of bertosamil salicylate having a melting range of 118.4 to 119.5 ° C. were obtained. The base:acid ratio determined by titration was 1:1.0. Thermogravimetric analysis showed no weight loss on drying.

Provenance & Evidence