Hydrochloric Acid → 132523-84-3

Participants

Reaction Steps

2 g (=0.0069 mole) of tedisamil were dissolved in 5 ml of isopropanol. A solution of 0.53 g of hydrochloric acid in 5 ml of isopropanol was added with stirring to this solution. After the formation of salts, isopropanol was removed by distillation, and the tedisamil dihydrochloride which remained as a residue was recrystallized from acetone and dried at 60° C. in a vacuum drying oven. 2 g of tedisamil dihydrochloride were obtained. DSC gave a melting range with decomposition at 225.7 to 240.4° C. The base:acid ratio determined by titration was 1:2.0. Thermogravimetric analysis showed a 0.2% weight loss on drying.

Provenance & Evidence