反应详情

Spiro[1H-indene-1,4'-piperidine]hydrochloride (400 mg, 1.8 mmol), prepared according to Example 1, step 3, was dissolved in water (10 ml), and the solution made alkaline with sodium carbonate. The mixture was extracted with dichloromethane (3×10 ml), the organic layers separated, dried (MgSO4) and evaporated in vacuo. The free base was used without any further purification.

1. extractionThe mixture was extracted with dichloromethane (3×10 ml)
2. customthe organic layers separated
3. dry with materialdried (MgSO4)
4. customevaporated in vacuo
5. customThe free base was used without any further purification