Sodium Carbonate → Spiro[indene-1,4'-piperidine]

HRID 1110044Notes

Reaction equation

HRID 1110044 reaction equation
Cl.[NH:2]1[CH2:7][CH2:6][C:5]2([C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[CH:9]=[CH:8]2)[CH2:4][CH2:3]1.C(=O)([O-])[O-].[Na+].[Na+]>O>[NH:2]1[CH2:7][CH2:6][C:5]2([C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[CH:9]=[CH:8]2)[CH2:4][CH2:3]1

Participants

4

Reactant 2

HCID 10340Sodium CarbonateHCID 22509344Spiro[indene-1,4'-piperidine] hydrochloride

Product 1

HCID 10330052Spiro[indene-1,4'-piperidine]

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Spiro[1H-indene-1,4'-piperidine]hydrochloride (400 mg, 1.8 mmol), prepared according to Example 1, step 3, was dissolved in water (10 ml), and the solution made alkaline with sodium carbonate. The mixture was extracted with dichloromethane (3×10 ml), the organic layers separated, dried (MgSO4) and evaporated in vacuo. The free base was used without any further purification.

Workup

  1. extractionThe mixture was extracted with dichloromethane (3×10 ml)
  2. customthe organic layers separated
  3. dry with materialdried (MgSO4)
  4. customevaporated in vacuo
  5. customThe free base was used without any further purification

Sources & evidence

ORD record
ord-200b2f52d402459d8bef0f27cc92a81d
Source dataset
uspto-grants-1994_06
Patent number
US05324733

Reaction notes

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