Thionyl Chloride → HCID 19018948, compound

Participants

Reaction Steps

4.45 gm (14.3 mmol) of ethyl 6,7-difluoro-1,4-dihydro-1-(1-hydroxyprop-2-yl)-4-oxoquinoline-3-carboxylate and 5.10 gm (42.9 mmol) of thionyl chloride were dissolved into 130 ml of chloroform for reaction with heating under refluxing for 1 hour. After cooling, the solvent was evaporated under reduced pressure, the residue was purified by silica gel column chromatography (chloroform:methanol=100:1), and recrystallized from ethanol to obtain 3.53 gm of colorless, needlelike crystals of ethyl 1-(1-chloroprop-2-yl)-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate:

Provenance & Evidence