HCID 19018387, compound → 7-[(Perfluorobutyryl)amino]-4-chloro-3-methoxy-1H-2-benzopyran-1-one

HRID 1110074Notes

Reaction equation

HRID 1110074 reaction equation
FC1C=C(C=CC=1)C(NC1C=C2C(C(Cl)=C(OCCC)OC2=O)=CC=1)=O.COC1C=CC(C(NC2C=C3C(C(Cl)=C(OCCC)OC3=O)=CC=2)=O)=CC=1.[F:54][C:55]([F:81])([C:77]([F:80])([F:79])[F:78])[C:56]([F:76])([F:75])[C:57]([NH:59][C:60]1[CH:70]=[C:69]2[C:63]([C:64]([Cl:74])=[C:65]([O:71][CH2:72]C)[O:66][C:67]2=[O:68])=[CH:62][CH:61]=1)=[O:58].FC(F)(C(F)(F)F)C(F)(F)C(NC1C=C2C(C(Cl)=C(OCCBr)OC2=O)=CC=1)=O.FC1C=C(C=CC=1)C(NC1C=C2C(C(Cl)=C(OCCBr)OC2=O)=CC=1)=O.[N+](C1C=C(C=CC=1)C(NC1C=C2C(C(Cl)=C(OCCBr)OC2=O)=CC=1)=O)([O-])=O.C1(CS(NC2C=C3C(C(Cl)=C(OCCBr)OC3=O)=CC=2)(=O)=O)C=CC=CC=1>>[F:81][C:55]([F:54])([C:77]([F:78])([F:79])[F:80])[C:56]([F:75])([F:76])[C:57]([NH:59][C:60]1[CH:70]=[C:69]2[C:63]([C:64]([Cl:74])=[C:65]([O:71][CH3:72])[O:66][C:67]2=[O:68])=[CH:62][CH:61]=1)=[O:58]

Participants

8

Reactant 7

HCID 19018387HCID 19018387, compoundHCID 19018394HCID 19018394, compoundHCID 19018403HCID 19018403, compoundHCID 19018412HCID 19018412, compoundHCID 19018424HCID 19018424, compoundHCID 19018437HCID 19018437, compoundHCID 19018438HCID 19018438, compound

Product 1

HCID 150220047-[(Perfluorobutyryl)amino]-4-chloro-3-methoxy-1H-2-benzopyran-1-one

Procedure

7-(3-fluorobenzoyl)amino-4-chloro-3-propoxyisocoumarin, 7-(4-methoxybenzoyl)amino-4-chloro-3-propoxyisocoumarin, 7-heptafluorobutyroylamino-4-chloro-3-ethoxyisocoumarin, 7-heptafluorobutyroylamino-4-chloro-3-(2-bromoethoxy)isocoumarin, 7-(3-fluorobenzoyl)amino-4-chloro-3-(2-bromoethoxy)isocoumarin, 7-(3-nitrobenzoyl)amino-4-chloro-3-(2-bromoethoxy)isocoumarin, 7-(α-toluenesulfonyl)amino-4-chloro-3-(2-bromoethoxy)isocoumarin can be prepared by the same procedure.

Sources & evidence

ORD record
ord-2cf30d84c23743658ff3b5f1ae8044f1
Source dataset
uspto-grants-1994_06
Patent number
US05324648

Reaction notes

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