3,4-dihydro-2H-pyran → HCID 19019069, compound

Participants

Reaction Conditions

Reaction Steps

To 100 g (0.73 mol) of the 3,4-dihydroxystyrene prepared in a) are added 320 g (3.8 mol) of dihydropyran and a few drops of concentated hydrochloric acid. The reaction mixture is stirred for 12 h at 40° C. The solution is then diluted with diethyl ether and poured on to ice. The organic phase is washed twice at 0° C. with 1N NaOH, dried, and treated with activated carbon. After filtration and concentration of the filtrate there is obtained a colourless viscous liquid which is chromatographed over a column of silica gel with a 4:1 mixture of hexane/ethyl acetate.

Provenance & Evidence