Sodium Hydroxide → HCID 19389115, compound

Participants

Reaction Steps

A solution of 1.88 g (4.47 mmol) of N-[4-[(decylamino)carbonyl]phenyl]-N-(2-methoxy-2-oxoethyl)glycine methyl ester and 17.0 ml (17.9 mmol) of 1 N NaOH in 125 ml of methanol was kept at room temperature for 18 hours. The solvent was removed, water was added to the residue and the pH was adjusted to 2 with 6 N HCl. The precipitate was filtered and recrystallized from methanol-water to give 1.63 g (93% yield, mp 155°-157°) of N-(carboxymethyl)-N-[4-[(decylamino)carbonyl]phenyl]glycine.

Provenance & Evidence