Sodium Hydroxide → HCID 19389003, compound

Participants

Reaction Steps

A solution of 0.53 g (0.93 mmol) of N-(2-methoxy-2-oxoethyl)-N-[3-(methylsulfinyl)-5-(octadecyloxy)phenyl]glycine methyl ester and 0.8 ml (4.7 mmol) of 6 N NaOH in 40 ml of methanol was stirred at reflux under argon for 6 hours. The solvent was removed at reduced pressure, the residue was acidified and the product was extracted with 10% THF-ethyl acetate. The dried extract was concentrated to a solid which was recrystallized from THF-ethyl acetate to give 0.42 g (84% yield), mp 147°-149°, of N-(carboxymethyl)-N-[3-(methylsufinyl)-5-(octadecyloxy)phenyl]glycine.

Provenance & Evidence