Methanol → 2-Iodo-6-methoxypyrazine

2,6-Diiodopyrazine (5.0 g, 15 mmol) was added to a solution of sodium methoxide in methanol (prepared from sodium (0.35 g, 15 mmol) and methanol (40 ml)) and the mixture was heated at reflux temperature for 1 hour. After cooling, the solution was diluted with water (200 ml) and extracted with diethylether (3×100 ml). The combined extracts were washed with water, dried over magnesium sulphate and concentrated under reduced pressure to give the product as a white solid (3.5 g, 100%) m. pt. 35.7-37.2

1. temperaturethe mixture was heated
2. temperatureat reflux temperature for 1 hour
3. temperatureAfter cooling
4. extractionextracted with diethylether (3×100 ml)
5. washThe combined extracts were washed with water
6. dry with materialdried over magnesium sulphate
7. concentrationconcentrated under reduced pressure

ORD record

ord-c1cca32c35194c228b6908ac057c6531

Source dataset

uspto-grants-1990_12

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04975112