反应详情

To a solution of 1.6M n-butyl lithium in n-hexane (16.5 ml) in toluene (20 ml) at -70° C., under nitrogen, was added a solution of 2-bromo-6,7,8,9-tetrahydro-3-methyl-5H-cyclohepta[b]pyridine (6 g 0.025 m) and the mixture kept at -20° C. for 0.25 hours. This was blown over into a solution of 2-thiophenecarboxaldehyde (3.0 g) in toluene (30 ml) kept at -20° C., then allowed to warm to room temperature and water added. The organic phase was extracted with 2N hydrochloric acid, then basified with solid potassium carbonate and extracted with chloroform. The combined chloroform extracts were dried (MgSO4) and evaporated. The residue was recrystallised from n-hexane to give the title compound (4.42g), m.p. 102°-4° C.

1. customkept at -20° C.
2. extractionThe organic phase was extracted with 2N hydrochloric acid
3. extractionextracted with chloroform
4. dry with materialThe combined chloroform extracts were dried (MgSO4)
5. customevaporated
6. customThe residue was recrystallised from n-hexane