Isatin → HCID 178442075, compound

Participants

Reaction Steps

A suspension of the isatin described in Example 10c (5.51 g) in ethanol (20 ml) was warmed slightly followed by addition of hydroxylamine hydrochloride (2.47 g) dissolved in water (10 ml). The mixture was warmed to about 80° with stirring for 10 minutes, followed by cooling to ambient temperature and stirring for 30 minutes. The precipitated yellow solid was filtered off, washed with water and dried to afford the title product (4.50 g, 76%) as a fluffy yellow powder; tlc, Rf =0.16, silica gel, ethyl acetate:hexane (2:3).

Provenance & Evidence