反应详情

To a stirred mixture of 20 parts of 2-methyl-4-(phenylmethyl)piperazine, 11.13 parts of sodium carbonate and 120 parts of 2propanone were added dropwise 16.28 parts of 4-chloro-2-methylbutanoyl chloride. Upon completion, stirring was continued for 45 minutes. The precipitated product was filtered off and taken up in dichloromethane. Water and sodium carbonate were added. The organic layer was separated, dried, filtered and evaporated. The residue was converted into the hydrochloride salt in 2-propanol. The salt was filtered off and dried in vacuo at 40° C., yielding 16.5 parts (45.5%) of 1-(4- chloro-2-methyl-1-oxobutyl)-2-methyl-4-(phenylmethyl)piperazine monohydrochloride (int. 25).

1. filtrationThe precipitated product was filtered off
2. additionWater and sodium carbonate were added
3. customThe organic layer was separated
4. customdried
5. filtrationfiltered
6. customevaporated
7. filtrationThe salt was filtered off
8. customdried in vacuo at 40° C.