Thionyl Chloride → HCID 15078443, Verbindung

HRID 1110385Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1110385
O[CH2:2][CH2:3][N:4]([CH3:12])[C:5]([N:7]1[CH2:11][CH2:10][CH2:9][CH2:8]1)=[O:6].S(Cl)([Cl:15])=O>CN(C)C=O.CC1C=CC=CC=1>[Cl:15][CH2:2][CH2:3][N:4]([CH3:12])[C:5]([N:7]1[CH2:11][CH2:10][CH2:9][CH2:8]1)=[O:6]

Komponenten

5

Edukt 2

HCID 24386Thionyl ChlorideHCID 15078442N-(2-hydroxyethyl)-N-methyl-1-pyrrolidinecarboxamide

Produkt 1

HCID 15078443HCID 15078443, VerbindungAusbeute 100 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6228DimethylformamideKatalysatorHCID 1140TolueneLösungsmittel

Versuchsvorschrift

To a stirred solution of 4 parts of N-(2-hydroxyethyl)-N-methyl-1pyrrolidinecarboxamide in 22.5 parts of methylbenzene were added 2.9 parts of thionyl chloride. After the addition of a few drops of N,N-dimethylformamide, the reaction mixture was heated slowly to reflux temperature. After stirring for 2 hours at this temperature, the mixture was cooled and the whole was evaporated, yielding 4.5 parts (100%) of N-(2-chloroethyl)-N-methyl-1-pyrrolidinecarboxamide as a residue (int. 31).

Aufarbeitung

  1. temperaturethe reaction mixture was heated slowly
  2. temperatureto reflux temperature
  3. temperaturethe mixture was cooled
  4. customthe whole was evaporated

Quellen und Nachweise

ORD-Eintrag
ord-5236f34808b046a5a218be6f19255da4
Quelldatensatz
uspto-grants-1990_12
Patentnummer
US04975439

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