5-Chloro-2-hydroxy-3-methylbenzaldehyde → 1-(6-chloro-8-methyl-2H-chromen-3-yl)ethan-1-one

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Reaction Steps

Using the procedure described in Example 1, stage A, but with 2-hydroxy-3,5-dimethylbenzaldehyde replaced by 2-hydroxy-3-methyl-5-chlorobenzaldehyde, the expected product is obtained, and this is purified by an additional recrystallization in an isopropyl ether/petroleum ether mixture.

Provenance & Evidence