HCID 15078404, compound → HCID 15078407, compound

Participants

Reaction Steps

818 mg of methyl 3-{[2-[(4-chlorophenyl)sulfonylamino]indan-5-yl]oxyacetylamino}propionate are dissolved in 10 ml of methanol, and an aqueous In sodium hydroxide solution is added to the solution. The mixture is stirred at room temperature for 3 hours. The reaction mixture is evaporated to remove methanol and the residue is acidified with an aqueous 10% hydrochloric acid solution. The mixture is extracted with ethyl acetate. The extract is washed successively with an aqueous saturated sodium hydrochloride solution, dried and evaporated to remove solvent. The residue is recrystallized from a mixture of tetrahydrofuran and isopropyl ether to give 750 mg of 3-{[2-[(4-chlorophenyl)sulfonylamino]indan-5-yl]oxyacetylamino}propionic acid as colorless prisms. Yield: 92%

Provenance & Evidence