Chloroform → HCID 15078414, compound

Participants

Reaction Steps

To a suspension of 5.03 g of 2-acetylamino-5-chloroacetylindan in chloroform are added 6.8 g of sodium dihydrogenphosphate and 10.06 g of m-chloroperbenzoic acid, and the mixture is refluxed for 5 hours under stirring. The reaction mixture is evaporated to remove solvent and the residue is extracted with ethyl acetate. The extract is washed successively with an aqueous sodium bicarbonate solution and an aqueous 10% hydrochloric acid solution, dried and evaporated to remove solvent. The residue is recrystallized from ethyl acetate-n-hexane-isopropyl ether to give 2.6 g of 2-acetylamino-5-chloroacetoxyindan. Yield: 48%

Provenance & Evidence