HCID 86744375, compound → HCID 86744374, compound

Participants

Reaction Steps

2-[[[1-[2 [[(1,1-Dimethylethoxy)carbonyl]amino]-4-thiazolyl]-2-[[1-[[[[3-[[(1,4-dihydro-4-oxo-5-hydroxy-2-pyridinyl)carbonyl]amino]-2,5-dioxo-1-imidazolidinyl]sulfonyl]amino]carbonyl]-2-oxo-3-azetidinyl]amino]-2-oxoethylidene]amino]oxy]-2-methyl propanoic acid 1,1-dimethylethyl ester (833 mg) is cooled to 0° C. and dissolved in cold trifluoroacetic acid (20 ml). After 45 minutes, the solution is warmed to room temperature, stirred for 2 hours and concentrated. The residue is dissolved in 1:1::acetonitrile:water (6 ml) and chromatographed over HP-20 to give the title compound. Physical characteristics are as follows:

Provenance & Evidence