反应详情

A mixture of (E)-5,5-bis(4-chlorophenyl)-2,4-pentadienoic acid ethyl ester (7.5 g) in methanol (30 mL) and 2N sodium hydroxide solution (15 mL) was heated at reflux for 30 minutes. The crude solid obtained from the usual work up, was crystallized from ether-hexane to yield 6.55 g of (E)-5,5-bis(4-chlorophenyl)-2,4-pentadienoic acid, mp 213°-215° C. Recrystallization of a portion from 2-propanol furnished the analytical sample, mp 214°-215° C. Anal. Calculated for C17H12Cl2O2 : C, 63.97; H, 3.79; Cl. 22.21 Found: C, 63.80; H, 3.90; Cl, 21.99.

1. temperaturewas heated
2. temperatureat reflux for 30 minutes
3. customThe crude solid obtained from the usual work up,
4. customwas crystallized from ether-hexane