Pyridine, 3-(4-aminobutyl)- → HCID 14347346, compound

Participants

Reaction Steps

As in Example 134, (E)-5,5-diphenyl-2-methyl-2,4-pentadienoic acid 4-nitrophenyl ester (1.6 g) was reacted with 3-pyridinebutanamine (0.63 g) for 18 hours at 25° C. The crude amide obtained from the usual work up was purified by HPLC (ethyl acetate) and then crystallized from ether to provide 1.42 g of (E)-5,5-diphenyl-2-methyl-N-[4-(3-pyridinyl)butyl]2,4-pentadienamide mp 93°-94° C. Anal. Calculated for C27H28N2O: C, 81.78; H, 7.12; N, 7.06 Found: C, 81.74; H, 7.02; N, 7.01.

Provenance & Evidence