Pyridine, 3-(4-aminobutyl)- → HCID 14347343, compound

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Reaction Steps

As in Example 134, a solution of (E)-5,5-bis[3-(trifluoromethyl)phenyl]-2,4-pentadienoic acid 4-nitrophenyl ester (4.8 g) and 3-pyridinebutanamine (1.5 g) in tetrahydrofuran (20 mL) was stirred for 2 hours at room temperature and was then worked up in the usual manner. The crude product was purified by HPLC (ethyl acetate) and then crystallized from ether-hexane to afford 3.2 g of (E)-5,5-bis[3-(trifluoromethyl)phenyl]-N-[4-(3-pyridinyl)butyl]-2,4-pentadienamide mp 89°-90° C. Anal Calculated for C28H24F6N2O : C, 64.86; H, 4.67; F, 21.98; N, 5.40 Found: C, 64.82; H, 4.72; F, 22.19; N, 5.38.

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