Tetrahydrofuran → HCID 22155197, compound

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Reaction Steps

As in Example 134, a solution of (2E,4E)-5-(3-methoxyphenyl)-5-phenyl-2,4-pentadienoic acid 4-nitrophenyl ester (2.96 g) and 3-pyridinebutanamine (1.107 g) in tetrahydrofuran (15 mL) was stirred for 1 hour at room temperature. After the usual work up, the crude amide was purified by HPLC (ethyl acetate) and then crystallized from ethyl acetate-hexane to provide 2.5 g of (2E,4E)-5-(methoxyphenyl)-5-phenyl-N-[4-(3-pyridinyl)butyl]-2,4-pentadienamide mp 66°-68° C. Anal. Calculated for C28H28N2O2 : C, 78.61; H, 6.84; N. 6.79 Found: C, 78.42; H, 6.88; N, 6.79.

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