Acetic acid, 2-(triphenylphosphoranylidene)-, methyl ester → HCID 86742583, compound

Participants

Reaction Steps

As described in Example 99, (E)-3-(3-fluorophenyl)-2-octenal (5.43 g) was treated with (carbomethoxymethylene)triphenylphosphorane (9 g) in dichloromethane (50 mL) for 4 days at room temperature. The ester was isolated in the usual manner and purified by HPLC (ether-hexane; 1:9) to provide 6.04 g of (E,E)-5-(3-fluorophenyl)-2,4-decadienoic acid methyl ester as an oil.

Provenance & Evidence