HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(3-Pyridyloxy)propylamine → (E)-5.5-bis(4-methoxyphenyl)-N-[3-[(3-pyridinyl)oxy]propyl]-2,4-pentadienamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(3-Pyridyloxy)propylamine | HCID 10219540 | — |
| Reactant | (E)-5,5-bis(4-methoxyphenyl)-2,4-pentadienoic acid 4-nitrophenyl ester | HCID 14347315 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | (E)-5.5-bis(4-methoxyphenyl)-N-[3-[(3-pyridinyl)oxy]propyl]-2,4-pentadienamide | HCID 14347373 | 82.5% |
Reaction Steps
As described in Example 134, a solution of (E)-5,5-bis (4-methoxyphenyl)-2,4-pentadienoic acid 4-nitrophenyl ester (1.0 g) and 3-(3-pyridinyloxy)proPanamine (0.4 g) in tetrahydrofuran (10 mL) was stirred overnight at room temperature. After the usual work up, the crude product was crystallized from ethyl acetate-hexane to give 0.85 g of (E)-5.5-bis(4-methoxyphenyl)-N-[3-[(3-pyridinyl)oxy]propyl]-2,4-pentadienamide, mp 146°-147° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04975438 |
| Source dataset | uspto-grants-1990_12 |
| ORD ID | ord-72cda106b6fc4b1abca6aeb96acc583e |
| Source note | uspto-grants-1990_12 |