Pyridine, 3-(4-aminobutyl)- → HCID 22155253, compound

HRID 1110631Notes

Reaction equation

HRID 1110631 reaction equation
[N+](C1C=CC([O:10][C:11](=O)/[CH:12]=[CH:13]/[CH:14]=[C:15](\[C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=2[O:30][CH3:31])/[C:16]2[CH:21]=[CH:20][C:19]([O:22][CH3:23])=[CH:18][CH:17]=2)=CC=1)([O-])=O.[N:33]1[CH:38]=[CH:37][CH:36]=[C:35]([CH2:39][CH2:40][CH2:41][CH2:42][NH2:43])[CH:34]=1>>[CH3:31][O:30][C:25]1[CH:26]=[CH:27][CH:28]=[CH:29][C:24]=1/[C:15](/[C:16]1[CH:17]=[CH:18][C:19]([O:22][CH3:23])=[CH:20][CH:21]=1)=[CH:14]\[CH:13]=[CH:12]\[C:11]([NH:43][CH2:42][CH2:41][CH2:40][CH2:39][C:35]1[CH:34]=[N:33][CH:38]=[CH:37][CH:36]=1)=[O:10]

Participants

3

Reactant 2

HCID 72927Pyridine, 3-(4-aminobutyl)-HCID 14347446HCID 14347446, compound

Product 1

HCID 22155253HCID 22155253, compoundYield 96.3%

Procedure

As before in Example 134, a solution of (2E,4Z)-5-(2-methoxyphenyl)-5-(4-methoxyphenyl)-2,4-pentadienoic acid 4-nitrophenyl ester (0.82 g) and 3-pyridinebutanamine (0.33 g) in tetrahydrofruan (7 mL) was stirred overnight at room temperature. After the usual work up. the crude product was purified by HPLC (ethyl acetate) and lyophilized from benzene to give 0.81 g of (2E,4Z)-5-(2-methoxyphenyl)-5-(4-methoxyphenyl)-N-[4-(3-pyridinyl)butyl]-2,4-pentadienamide as an amorphous solid.

Workup

  1. customthe crude product was purified by HPLC (ethyl acetate)

Sources & evidence

ORD record
ord-8543eb59b1794928bebe506b2b0b3eb0
Source dataset
uspto-grants-1990_12
Patent number
US04975438

Reaction notes

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