Hydrochloric Acid → 4-amino-N-methylbenzene-1-sulfonamide

Participants

Reaction Steps

The acetamide (1.6 g) was dissolved in methanol (5 ml) and refluxed, with an addition of 4N hydrochloric acid (7 ml), for 1 hour. After an evaporation of methanol under a reduced pressure, the residue was made basic with an addition of 1N sodium hydroxide, and extracted with ethyl acetate (30 ml), followed by drying over anhydrous sodium sulfate. Evaporation of the solvent under a reduced pressure gave N-methyl-4-(amino)benzenesulfonamide (1.2 g) (m.p. 110.9° C.-112° C.).

Provenance & Evidence