Potassium Hydroxide → 2-Hydroxy-7-(2-octyloxy)-fluorene

HRID 1110684Notes

Reaction equation

HRID 1110684 reaction equation
[CH3:1][CH:2](Br)[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8].[OH:10][C:11]1[CH:23]=[CH:22][C:21]2[C:20]3[C:15](=[CH:16][C:17]([OH:24])=[CH:18][CH:19]=3)[CH2:14][C:13]=2[CH:12]=1.[OH-].[K+]>C(O)C>[OH:10][C:11]1[CH:23]=[CH:22][C:21]2[C:20]3[C:15](=[CH:16][C:17]([O:24][CH:2]([CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8])[CH3:1])=[CH:18][CH:19]=3)[CH2:14][C:13]=2[CH:12]=1

Participants

5

Reactant 3

HCID 14797Potassium HydroxideHCID 79046Sec-octyl bromide, (+-)-HCID 149383839H-Fluorene-2,7-diol

Product 1

HCID 221539162-Hydroxy-7-(2-octyloxy)-fluorene

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

According to a known method, optically active 2-octyl bromide and 2,7-dihydroxyfluorene were reacted in ethanol in the presence of potassium hydroxide. The resultant reaction mixture was purified by a column chromatography and recrystallization to obtain optically active 2-hydroxy-7-(2-octyloxy)-fluorene.

Workup

  1. customThe resultant reaction mixture
  2. customwas purified by a column chromatography and recrystallization

Sources & evidence

ORD record
ord-cdfe2e0ab9184faeb5101376a36075af
Source dataset
uspto-grants-1990_12
Patent number
US04976887

Reaction notes

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