Water → HCID 14852211, compound

HRID 1110708Notes

Reaction equation

HRID 1110708 reaction equation
[OH-].[Na+].O.[CH3:4][N:5]1[CH2:10][CH2:9][N:8]([CH2:11][C:12]([C:14]2[CH:19]=[CH:18][C:17]([NH:20]C(=O)C)=[CH:16][CH:15]=2)=[O:13])[CH2:7][CH2:6]1>C(O)C>[CH3:4][N:5]1[CH2:6][CH2:7][N:8]([CH2:11][C:12]([C:14]2[CH:19]=[CH:18][C:17]([NH2:20])=[CH:16][CH:15]=2)=[O:13])[CH2:9][CH2:10]1

Participants

5

Reactant 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 14852210HCID 14852210, compound

Product 1

HCID 14852211HCID 14852211, compoundYield 79.7%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
85 °C

Procedure

1.8 g of sodium hydroxide dissolved in 10 ml of ethanol and 10 ml of water were added to 4.0 g of 2-(4-methylpiperazin-1-yl)-1-(4-acetylamino-phenyl)-ethanone which was obtained in the same manner as in Example 1, and stirred at 85° C for 2 hours in a nitrogen atmosphere. Then, ethanol was distilled off, the deposited oily product was extracted with chloroform, washed with water, dried over anhydrous sodium sulfate and further concentrated to solid to obtain 2.7 g of 2-(4-methylpiperazin-1-yl)-1-(4-amino-phenyl)-ethanone.

Workup

  1. customwas obtained in the same manner as in Example 1
  2. distillationThen, ethanol was distilled off
  3. extractionthe deposited oily product was extracted with chloroform
  4. washwashed with water
  5. dry with materialdried over anhydrous sodium sulfate
  6. concentrationfurther concentrated to solid

Sources & evidence

ORD record
ord-7a6584f3c6f047208bb28ca90b1ebf47
Source dataset
uspto-grants-1990_12
Patent number
US04977151

Reaction notes

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