HCID 22154140, compound → HCID 22154147, compound

HRID 1110720Notes

Reaction equation

HRID 1110720 reaction equation
C(OC([NH:11][CH2:12][CH2:13][CH2:14][C:15]([NH:17][C:18]1[CH:19]=[C:20]2[C:24](=[CH:25][CH:26]=1)[NH:23][CH:22]=[CH:21]2)=[O:16])=O)C1C=CC=CC=1.[H][H]>[Pd].CO>[NH2:11][CH2:12][CH2:13][CH2:14][C:15]([NH:17][C:18]1[CH:19]=[C:20]2[C:24](=[CH:25][CH:26]=1)[NH:23][CH:22]=[CH:21]2)=[O:16]

Participants

5

Reactant 2

HCID 22154140HCID 22154140, compoundHCID 178418361HCID 178418361, compound2×

Product 1

HCID 22154147HCID 22154147, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

4.56 of 4-(Benzyloxycarbonylamino)-N-(1H-indol-5-yl)butanamide, 1.1 g palladium (10%) on charcoal and 100 ml methanol are added together at room temperature in the presence of hydrogen until about 90% of theoretical hydrogen uptake is obtained (maximum uptake). The suspension is filtered through talc and the solvent evaporated off giving an oily residue of 4-amino-N-(1H-indol-5-yl)butanamide which is recrystallised from methanol/ether (M.P. 124°-136°).

Workup

  1. customis obtained (maximum uptake)
  2. filtrationThe suspension is filtered through talc
  3. customthe solvent evaporated off

Sources & evidence

ORD record
ord-bf76d727ff804d58bf9f690e91381902
Source dataset
uspto-grants-1990_12
Patent number
US04977153

Reaction notes

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