Piperazine → 5-Amino-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid

Participants

Reaction Steps

To 1.57 g (5.00 mmol) of 5-amino-8-chloro-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3quinolinecarboxylic acid in 20 ml of acetonitrile was added 1.7 g (20.0 mmol) of piperazine. The mixture was refluxed for four hours, cooled, filtered, and washed with acetonitrile to give 1.83 g of the title compound.

Provenance & Evidence