Methyl iodide → HCID 131716729, compound

HRID 1110730Notes

Reaction equation

HRID 1110730 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][C@:5]2([OH:22])[C:8]3[CH:21]=[CH:20][CH:19]=[CH:18][C:9]=3[O:10][C:11]3[C:16]([CH3:17])=[CH:15][CH:14]=[CH:13][C:12]=3[C@@H:4]2[CH2:3]1.[CH3:23][I:24]>C1(C)C=CC=CC=1.CCOCC.CO>[I-:24].[OH:22][C@@:5]12[C:8]3[CH:21]=[CH:20][CH:19]=[CH:18][C:9]=3[O:10][C:11]3[C:16]([CH3:17])=[CH:15][CH:14]=[CH:13][C:12]=3[C@@H:4]1[CH2:3][N+:2]([CH3:23])([CH3:1])[CH2:7][CH2:6]2

Participants

6

Reactant 2

HCID 6328Methyl iodideHCID 166560Beloxepin

Product 1

HCID 131716729HCID 131716729, compound

Reagents, catalysts & solvents 3

HCID 887MethanolSolventHCID 1140TolueneSolventHCID 3283Diethyl EtherSolvent

Procedure

5.0 g (17 mmol) of the compound of Example 1 were dissolved in a mixture of 200 ml of toluene, 100 ml of ether and 50 ml of methanol. While stirring 50 ml of methyl iodide were added at room temperature. After 24 hrs crystals had formed. The mother liquor was filtered off and the crystals collected. This gave 6.75 g (91%) of the quaternary iodide. m.p. >260° C. (dec.).

Workup

  1. additionwere added at room temperature
  2. customAfter 24 hrs crystals had formed
  3. filtrationThe mother liquor was filtered off
  4. customthe crystals collected

Sources & evidence

ORD record
ord-474b295b935546e3bb28af495cf37b92
Source dataset
uspto-grants-1990_12
Patent number
US04977158

Reaction notes

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