Acetic Anhydride → 2-Acetylpyrrolo[3,4-g]quinoline

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Reaction Steps

The pyrrolo[3,4-g]quinoline derivatives of formula (1) and (2) are prepared by reacting a 7-dimethylaminomethylene-6-oxo-trans-quinoline derivative of formula (7a) or (7b) with potassium glycinate, followed by treatment of the thus formed intermediate product with acetic anhydride. This yields a 2-acetylpyrrolo[3,4-g]quinoline compound. The acetyl group is removed by basic hydrolysis, for example using sodium ethoxide in ethanol. Preparation of the pyrrolo[3,4-g]quinolines of formula (1) is illustrated in Reaction Scheme III: ##STR18## The pyrrolo[3,4-g]quinolines of formula (2) are prepared using the same procedures and starting materials of formula (7b).

Provenance & Evidence